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Tumors simultaneously rewire antioxidantsactivating NRF2 and elevating GSH/thioredoxin systemscreating a narrow therapeutic window in which pushing ROS beyond buffering capacity triggers apoptosis or ferroptosis, whereas indiscriminate scavenging blunts therapy and fosters resistance (Reczek and Chandel 2017)

Cellular uptake and biological outcomes rely entirely on individual metabolic absorption, existing systemic levels, and overall baseline health

doi: 10.1056/nejmoa2502081 [DOI] [PubMed] [Google Scholar] 17.Jones DW, Ferdinand KC, Taler SJ, Johnson HM, Shimbo D, Abdalla M, Altieri MM, Bansal N, Bello NA, Bress AP, et al

WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer

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