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Nuclear localization of the DAF-16 transcription factor is an indicator of insulin-like signalling, which occurs under stress conditions (Henderson and Johnson, 2001)

It only takes days to progress, and it is worsening over a day or two or three so that gets you a week or so plus/minus, outside maybe 2 weeks, Kaufman explains

Heberling CA, Dhurjati PS, Sasser M (2013) Hypothesis for a systems connectivity model of autism spectrum disorder pathogenesis: links to gut bacteria, oxidative stress, and intestinal permeability
[DOI] [PMC free article] [PubMed] [Google Scholar] [33].Avdeev SN, Gaynitdinova VV, Merzhoeva ZM, Berikkhanov ZGM

Hydrogen sulfide exposure induces apoptosis and necroptosis through lncRNA3037/miR-15a/BCL2-A20 signaling in broiler trachea
