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Under physiological conditions, GSH quenches oxidizing substances (such as reactive hydroxyl free radicals, peroxynitrite, and H 2 O 2 ) directly or reduces hydrogen peroxide (or lipid peroxide (lipid-OOH)) to water (or the corresponding lipid alcohol (lipid-OH)) under the catalysis of GPX (summarized in Fig

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For example, leukemia linked to chronic benzene exposure may develop within a few years, whereas cancers caused by asbestos or arsenic often take several decades to manifest, even after exposure has ceased [246]

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