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The Bcl2 exerts anti-apoptotic effect by impeding a step that leads to the activation of caspases, while BAX exerts proapoptotic activity [50]

doi: 10.3389/fmicb.2017.00980

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However, S downregulates Sirt3 levels, which further impairs mitochondrial functions (Park et al., 2020

[3] In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, increased rate of haemolysis, and defective function of the central nervous system