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The elevated IGF-1 levels as a result of insulin-resistance are thought to be responsible for vascular deterioration and modulation of its levels may help to mitigate these adverse effects [76]

GlyT1 is primarily localized in astrocytes surrounding glycinergic and glutamatergic synapses and is widely distributed throughout the CNS

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Clin Transl Med (2017) 6:25

All current treatment measures for PD only ameliorate and alleviate partial symptoms and signs in the early and middle stages
