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Lysosomal accumulation was observed in SMCR8 deficient macrophages from Smcr8 /mice , possibly because of increased ROS (Mcalpine et al., 2018)

Second, while our enzymatic assays suggest direct inhibition of G6PD by caffeine, these findings require further validation in vivo , particularly in G6PD-deficient individuals, in whom an exacerbated hemolytic phenotype was not observed

For instance, as functions independent of parasite infections, eosinophils have been shown to support IgA production and maintain gut plasma cells via secretion of survival factors (like APRIL and IL-6) in mice, thereby reinforcing the mucosal barrier against microbes (13, 14)

And granted there may be statistically more complications, but that's a really artificial kind of designation, right

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