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Toward a Genome Scale Sequence Specific Dynamic Model of Cell-Free Protein Synthesis in Escherichia Coli

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It is an E3 ubiquitin ligase that facilitates telomere protective protein 1 (TPP1) multisite polyubiquitination and accelerates degradation through binding to TPP1, thereby triggering telomere uncapping, cause cell senescence and tissue fibrosis (Wang L et al., 2020)

doi: 10.1146/annurev-bioeng-121219-024239

Endocrine, Metabolic and Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine and Metabolic Disorders) 9, 269276
