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doi: 10.1186/1471-2164-15-512

Although hyperfunctioning nodules may remain unchanged for years, some gradually develop into toxic nodules, especially if their diameter exceeds 3 cm (7)

The study protocol was approved by the ethical committee of TUMS

In addition, in patients with Alzheimers disease, LF supplementation led to the decreased expression of phosphatase and tensin homolog (PTEN), tau, and mitogen-activated protein kinase (MAPK1), as well as decreased serum levels of A42, which may indicate its beneficial effects on oxidative stress and inflammatory processes [152]