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Previous work has reported relatively increased Firmicutes and Proteobacteria and decreased Bacteroidetes in mice on an HFD, regardless of concomitant obesity (weight gain was minimized using a RELM knockout mouse 78 ) 78,79

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It causes blood thinning, so people taking some anticoagulants should not take the drug before surgery [219,225]

While semaglutide and tirzepatide are already widely used, emerging candidates like retatrutide, survodutide, cagrilintide, MOTS-c, and others are expanding the frontier of peptide-assisted weight management