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BH4 treatment resulted in an increase in methionine but this increase was only borderline significant [ F (1, 26) = 3.91, p = 0.06

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Reducing it is a higher-order benefit than surface antioxidant capacity. He adds that the focus on appearance alone such as wrinkle counts and photo-scoring will not disappear, but will be demoted to a secondary outcome, not a primary claim of efficacy on product labels