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Ann Surg 242(3):392-9

Overall, 30% of the deaths in patients with Type 1 HH are caused by hepatocellular carcinoma, with other complications of cirrhosis contributing another 20%.34-36 Sudden death is most commonly due to cardiac arrhythmias

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This network perspective shifts the goal of locoregional biomaterials from drug loading to triggerable, durable, and experimentally testable immunomodulation aligned with microenvironmental bottlenecks ( Figure 4 )