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10.1126/science.3952506 198 RapinI

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CagriSema dosing and protocols Simultaneous start (standard): Both peptides from week 1 Semaglutide: Standard titration to 2.4mg (16 weeks) Cagrilintide: Standard titration to 2.4mg (12 weeks) Both at maximum by week 17 Sequential approach: Start semaglutide, titrate to 2.4mg Stabilize 4-8 weeks Add cagrilintide starting 0.6mg Titrate cagrilintide to 2.4mg Both at maximum by week 30-34 Expected timeline (simultaneous): Month 3: 10-16 lbs lost Month 6: 22-32 lbs lost Month 12: 40-55 lbs lost Month 18: 50-65 lbs lost (15-25% total) Cost considerations: Research peptides: $500-900/month combined Annual cost: $6,000-10,800 Pharmaceutical CagriSema (when approved): $1,200-1,500/month likely Compare to bariatric surgery: $20,000-25,000 upfront Use SeekPeptides to plan your CagriSema protocol

Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis