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10.1016/j.nrl.2014.08.004 Neurol

10.1186/s12967-022-03659-2 95

U., Zhao, Y

In a clinical trial, pure genistein supplementation (54 mg/day, P.O for one year) improved both cardiac function and left atrial remodeling in postmenopausal women with metabolic syndrome [138]

This is the most reproducible early signal users describe and is consistent with IGF-1's insulin-like activity
