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and the use of antivirals that enhance activation of the Nrf2 transcription factor together with N-acetylcysteine administration restore GSH levels correcting the SARS-CoV-2-mediated impaired GSH metabolism (Aquilano et al., 2014
Jul 2016;20(3):261-70

In addition, increased expression of TGF also reduces expression of Notch ligand and receptor in aged skeletal muscle and contributes to loss of muscle mass and function with aging[30]

doi: 10.1016/j.it.2018.04.002 5 Allam-NdoulB.Pulido-MateosE
Recent studies have identified new outcomes of hepatocellular injury, such as ferroptosis, a specific form of iron-dependent cell death that is closely associated with the pathogenesis of MASLD, given the livers propensity for iron metabolism and lipid peroxidation