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It has been demonstrated that the promotion of HDAC4 phosphorylation is found after overexpression of CDKL5 via facilitating the cytoplasmic retention of HDAC4 while loss of CDKL5 leads to the decrease of HDAC4 phosphorylation, ultimately increasing the translocation of HDAC4 into the nucleus [105]

For example, the NF-B p65 subunit can suppress NRF2s transcriptional activity by competing for coactivators, while NRF2-driven HO-1 expression can limit NF-B activation through carbon monoxide and biliverdin signaling [65,66]

3.4 Reactive oxygen species (ROS) and antioxidants in cancer chemoresistance Cancer chemoresistance is a significant challenge in oncology, referring to the ability of cancer cells to survive and proliferate despite chemotherapy [75]

Mannose-6-phosphate is also a substrate for mannose phosphate isomerase (MPI) which interconverts mannose-6-phosphate and fructose-6-phosphate

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