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Elevated glucose and lactate metabolism in active MS lesions have been revealed through investigations using magnetic resonance spectroscopy and positron emission tomography imaging and immunohistochemistry staining [30, 31]

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Confocal fluorescence analysis of SH-SY5Y cells expressing YFP-ArfGAP1 variants reveals that WT ArfGAP1, and to a greater extent the 3A mutant, mostly co-localize with the GM130-labeled Golgi complex, whereas ArfGAP1-3D adopts a distinct cytoplasmic-like localization (Figure 8A)