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These effects include inducing tumor microenvironment remodeling, promoting tissue hypoxia, driving metabolic reprograming in fibroid cells, and even increasing genomic instability to facilitate gene mutations (Figure 4)

Interestingly, finasteride also inhibits the activity of steroid 5-reductase, a soluble steroid reductase that belongs to the NADPH-dependent aldo-keto reductase (AKR) superfamily 43