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To clarify when HHEX is required for Abcb1b expression, we used Cyp11b1-Cre ERT2 Hhex flox/flox and Cyp11b1-Cre ERT2 Hhex wt/wt or flox/wt ( WT and Heterozygotes ) mice fed a tamoxifen chow for 4 weeks after puberty (Supplementary Fig

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