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However, these compounds have thus far not had been subjected to clinical trials, possibly because of unwanted side effects, including lower Ca 2+ transport or increased heme-oxygenase (HO-1) levels (Konorev et al., 2002)

It primarily affects patients between the ages of 30 and 50, and despite extensive research, no effective treatment has been found so far

632 Di-Huang-Yin-Zi effectively decreases ROS and MDA levels in prefrontal cortex, increases the expression of ferroptosis-related markers GPX4 and SLC7A11 and, and decreases iron deposition, thereby improving depressive symptoms and synaptic ultrastructure of cortical regions in post-stroke depressed (PSD) rats, suggesting that Di-Huang-Yin-Zi can reduce the symptoms and enhance function in PSD rats by inhibiting ferroptosis through SLC7A11/GPX4 pathway

34 13691382 Dong X, Zhang L, Milholland B, Lee M, Maslov AY, Wang T and Vijg J 2017 accurate identification of single-nucleotide variants in whole-genome-amplified single cells

Jun 17 2020;13(1):73