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Dihexa has a long half-life (approximately 12 days), so effects are cumulative and build over time

Those with diseases that affect the gut, such as Crohns disease or celiac disease, are also at risk ( Summary Those at greatest risk of vitamin B12 deficiency are vegans and vegetarians, who get little to no B12 from the diet

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Compared to the placebo group, patients receiving tirzepatide achieved substantial weight loss: 8.07% (7.5 kg) with the 5 mg dose, 10.79% (11.0 kg) with the 10 mg dose, and 11.83% (11.5 kg) with the 15 mg dose