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This variation in pO2, in particular, differentially regulates the compartmentalization and functioning of the transcription factors hypoxia-inducible factor-1 (HIF-1) and nuclear factor-B (NF-B)

This review synthesizes current advancements in FOXO-SIRT1 regulation, its emerging role in redox homeostasis, and its therapeutic relevance, offering insights into future strategies for combating metabolic dysfunction and aging-related diseases.
Consistently, Erastin-induced changes in ROS, GSH, and MDA levels were regulated by this axis, highlighting its role in ferroptosis
