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Description
Local versus systemic administration (e.g., injecting near an injury site versus distant systemic injection) has been compared in several studies, with both approaches showing efficacy, suggesting the peptide works through systemic signalling pathways rather than purely local mechanisms

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Mattson M.P

Ann Thorac Surg 113(1):200-208, 2022

Pure structural issues like severe disc extrusions or spinal stenosis show much more limited response

Vaccines continue to be our best tool to limit the impact of SARS-CoV-2
