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Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution

Differences in metabolite concentrations between patients with ME/CFS, long COVID and healthy controls in pgACC, dACC and muscle were examined using one-way ANOVA, or univariate general linear model where covariates were used

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Mar 27 2021;9(2)doi:10.3390/pharmacy9020071

The key molecules of mitochondrial biogenesis are peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1), nuclear respiratory factors (NRFs), and mitochondrial transcription factor A (TFAM) (Lee and Wei, 2005)