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Overall, approximately 68% of patients receiving chemotherapy develop CIPN within the first month of treatment (Seretny et al., 2014), the development of which is related to both single as well as cumulative drug doses

[DOI] [PubMed] [Google Scholar] 133.Sanghai N., Tranmer G.K

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PMID: 31801061 Anal Chem High-Throughput Reactive Desorption Electrospray Ionization Mass Spectrometry for Targeted Derivatization and Analysis of Poorly Ionized Small Molecules

Remarkably, the mutant proteins display a dominant behavior disrupting the assembly of the intermediate filament network and eliciting the formation of characteristic protein aggregates, known as Rosenthal fibers, in the cytoplasm of astrocytes