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The perivascular origin of pathological fibroblasts

Several factors are established to affect the transduction signals of VEGF, which include P13K/AKT pathway during hypoxia conditions, RAS/RAF/MAPK (ERK) pathway during normoxia and probably via the activation of EGFR in non-hypoxia conditions

NADH is considered an antioxidant in biological systems due its high reactivity with some free radicals, its high intracellular concentrations and the fact that it has the highest reduction power of all biologically active compounds [32]

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