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Matrix metalloproteinases (MMPs) are up-regulated by pro-inflammatory cytokines, as well as by acute phase proteins like serum amyloid A (SAA), with counter-regulatory inhibition by IL-4 and IL-13, and released into the circulation from damaged vascular endothelium

Research suggests it influences several overlapping biological systems simultaneously, which may explain why it shows up across such a wide range of tissue types in preclinical studies

[DOI] [PubMed] [Google Scholar] 131.Kattoor AJ, Pothineni NVK, Palagiri D, Mehta JL

Funding This study was supported by a research grant (3251) from Shahrekord University of Medical Sciences, Shahrekord, Iran

Insights into sperm cell motility signaling through sNHE and the CatSpers