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The third type of GRXs have a Cys-Cys-X-Cys or Cys-Cys-X-Ser sequence at the active site and are specific to higher plants
Mesothelioma, an aggressive cancer with limited treatment options 5 , is associated with asbestos exposure, which drives ROS-mediated DNA damage and promotes oncogenic signaling 6,7
The most common physiological substrate is thought to be methylgloxyal, which is notably formed from triose phosphate, either non-enzymically or as an intermediate in the triose-phosphate isomerase reaction (Maiti et al., 1997
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