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After incubation, ultracentrifugation (100 000 rpm) was used to remove the free PKH26 working solution
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The arrow marks the reactive site peptide bond of the inhibitors
Nature 194 , 11491151 (1962)
Its accelerated approval was primarily based on a compelling reduction in plasma neurofilament light chain (NfL), a biomarker of neuronal damage, which decreased by approximately 60% in the tofersen group compared to 20% in the placebo group (44)
