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Immunoregulatory genes involved in T cell development, activation, signaling, and innate immune response associated with vitiligo.4,28,49,50 Variants of the PTPN22 gene have been associated with several autoimmune diseases, such as rheumatoid arthritis or systemic lupus erythematosus, making it a gene with a relevant role in the context of autoimmune diseases.61 The IKZF4 and FOXP3 genes, which play a role in gene silencing in Tregs, have also been linked.62 Several genes related to melanocyte function and survival have been invovled in vitiligo (Table 4)

48 CT scan is not as reliable for distinguishing these diagnoses as colonoscopy or contrast enema studies