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doi: 10.1016/S0022-474X(99)00056-9

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122,123 By observing the impact on the disease phenotype, researchers can establish the causal relationship between the target gene and the disease

Glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) are involved in regulating systemic glucose homeostasis, including insulin secretion 269,270,271