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In an environment with elevated CD38 activity, such as seen in SSc lesional skin, administering NAD + precursors or enhancing NAD + synthesis will have limited effect on increasing NAD + levels, as elevated CD38 continues to degrade NAD +
The core Ala-Glu-Asp-Gly sequence and proposed mechanism are the same
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Furthermore, the mixture was stirred at 55 C for 12 h refluxed at 80 C for 36 h
