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Reward Pathways: GLP-1 RAs modulate the mesolimbic reward system (including the ventral tegmental area and nucleus accumbens), potentially reducing the hedonic drive to consume palatable foods and even moderating addictive behaviors (Zheng et al., 2024)

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doi: 10.1073/pnas.1409513111

The replacement of Cys-112 with Arg-112 in ApoE4 increases its binding affinity to low and very low density lipoproteins (LDL, VLDL), whereas ApoE3 and ApoE2 prefers high density lipoproteins (HDL) that are richer in cholesterol (Weisgraber, 1990)

A case-control study conducted by Enechukwu et al