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Second, GSNO may help maintain or restore endothelium derived NO signaling, preserving vasorelaxation, minimizing reperfusion-associated vasoconstriction, and supporting coronary perfusion

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First, only bulk RNA seq was performed in this study, which reflects averaged transcriptional changes and does not resolve the heterogeneous responses of distinct macrophage and chondrocyte subsets to Se/LDH@PEG-M

Proper function of glutathione also requires mineral cofactors such as selenium (to form glutathione peroxidase) and magnesium (to activate the glutathione synthetase enzyme)