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In the oral cavity, LL-37 (a cathelicidin), histatins (salivary peptides), and human beta-defensins (HBDs) are produced continuously but their expression is suppressed by chronic inflammation, poor nutrition, and aging, contributing to periodontal disease progression

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Mitochondria are both a source and target of ROS

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Plates were incubated for about 72 h at 30 C to compare H 2 O 2 tolerances by watching their growth

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GLUTATHIONE AND ABSORPTION Glutathione is not absorbed very well in the digestive tract rendering oral consumption not very effective

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139 Sirtuins are an additional class of NAD + -dependent HDACs whose activity is indirectly redox-regulated through their dependence on the NAD + /NADH ratio maintained by the TCA cycle and affected by mitochondrial ROS production

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