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Concomitantly, aging induces characteristic morphological changes in notochordal NP cells, including increased cell area, diameter, and vesicle content [46], and diminishes NPPC pluripotency, characterized by decreased expression of core pluripotency markers like POU5F1 (also known as OCT4) and NANOG (Fig

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Faster regulatory timelines, large patient pools, and state-backed investment have positioned China as a leader in early-phase and proof-of-concept trials, with a growing share of global clinical assets now originating there

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