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The substitution lowers the affinity of MTHFR and its cofactor, which promotes the thermolability and diminishes the enzyme activity

Presumably, oxidative stress is involved in the pathogenesis and complications associated with all three types of DM, and GPx1 plays a critical role in the regulation of oxidative stress [60]

The copper in GHK-Cu is chelated (bound to the peptide), which silences coppers redox activity and prevents the oxidative damage associated with free copper ions

Sci World J 16:8780704

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