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Development of the 503B Bulks List has been underway with the FDA
AAPS J 15:195218 Mohandas KM, Desai DC (1999) Epidemiology of digestive tract cancers in India
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This effect is primarily attributed to methylxanthines, such as theobromine, which induces LES relaxation through a mechanism similar to caffeine (Reference Fredholm190)
J Physiol 32:401467 Erdtmann-Vourliotis M, Mayer P, Ammon S et al (2001) Distribution of G-protein-coupled receptor kinase (GRK) isoforms 2, 3, 5 and 6 mRNA in the rat brain
