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Hershman randomized women receiving adjuvant taxane chemotherapy for early breast cancer evenly to either oral ALC 1,000 mg three times daily or matching placebo, for 24 weeks

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[158] found increased activity of choline acetyltransferase and expression of nerve growth factor (NGF) receptor in the striatum, and increased NGF protein levels in the hippocampus of rat pups after intracerebroventricular injection of ALCAR every other day from 021 days of age

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