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Description
used genome-wide profiling to identify genetic biomarkers (genetic signature) for metastasis-prone colorectal cancer as well as their perturbagenssubstances that modulated their expression
Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Craig Venter J (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori
Low-Moderate = robust animal data, no human RCTs
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In all 3 cases, potential alternative causes were evaluated and deemed unlikely based on history, physical examination, and basic workup
