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L'anello imidazolico dell'istidina e il centro di coordinazione principale per lo ione rame, elemento che caratterizza biologicamente il complesso
varies with administration technique

Additionally, FOXO transcription factors have recently been implicated in tumorigenesis: in fact, rhabdomyosarcomas present FOXO genes with a high percentage of mutations that render them insensitive to inhibition by AKT signaling 65

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