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Serotonergic System Shows Regional Specificity With Antidepressant Potential The April 2024 paper highlights substantia nigra serotonin increases as one of BPC-157s most consistent and robust effects, supported by gold-standard autoradiography measuring actual synthesis rates rather than just concentration

doi: 10.3389/fcell.2025.1596421 Received 19 March 2025 Accepted 22 April 2025 Published 13 May 2025 Volume 13 - 2025 Edited by Matteo Avella, Sidra Medicine, Qatar Reviewed by Jurandy Penitente-Filho, JPF Consultoria, Brazil Qi Yin, Carnegie Institution for Science, United States Updates Copyright 2025 Gmez-Elas, Luque, Oscoz-Susino, Novero, Briski, Ksparas, Steeman, Stival, Lavolpe, Julianelli, Geller, Attie, Vassena, Krapf and Buffone