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Increased ROS formation is associated with a suppressed activation of protein kinase B AKT/mTOR resulting in apoptosis of -cell (Chau et al

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Acknowledgements The cryo-EM data were collected at the Center of Cryo-Electron Microscopy, Zhejiang University

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Its cell surface localization from storage granules is caused by oxidative stress or exposure to pro-inflammatory signals, such as cytokines and endotoxin [62]