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Our study also raises safety concerns about carnitine supplements, especially in men, with direct relevance to those currently taking carnitine due to deficiency and for athletes and body-builders aiming to improve exercise performance

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Biotin in metabolism, gene expression, and human disease

10.1371/journal.pgen.1000504 PLoS Genet

Although direct clinical evidence for anti-HCC activity in humans is lacking, its ability to attenuate insulin resistance, oxidative stress, and the inflammation-fibrosis cascade may indirectly reduce HCC risk by optimizing the hepatic oncogenic microenvironment