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Moreover, some study results showed that the species richness index Chao1 of HT patients had a significant increase, which may indicate the excessive growth of intestinal bacteria [34, 36]

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In a meta-analysis of 10 placebo-controlled trials including over 71,000 subjects with or without diabetes at recruitment, treatment with SGLT2 inhibitors reduced the risk of heart failure hospitalization or cardiovascular death by 24% and lowered the risk of poor renal outcomes by 32% (Barbarawi 2021)
