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The lack of Piezo2 in sensory neurons accelerates gastric emptying and intestinal transport, and Piezo2 knockout mice exhibit diarrhea in bead-expulsion assays, suggesting that Piezo2 + sensory neurons are important factors involved in normal intestinal motility (110, 114)

Handbook of Clinical Neurology 211223 (2017)

Nevertheless, the excessive buildup of ROS, either as a result of normal energy metabolism or due to inflammation and exposure to environmental factors like tobacco smoke, has been linked to the development of cancer in both animal studies and human research [47]

In vitro investigation of human UDP-glucuronosyltransferase isoforms responsible for tacrolimus glucuronidation: predominant contribution of UGT1A4

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