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The HTML:TML ratio was decreased by IDH1 inhibition and rescued by KG (Extended Data Fig

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BMI 27.1 2.3 kg/m 2 ) were in the control group (CT)

[1] Some compounders suggest adding B12 to tirzepatide formulations based on theoretical concerns about vitamin B12 absorption, though it's important to note that clinical evidence specifically linking tirzepatide to B12 deficiency is lacking
During this period, no modifications in serum lipid profile and circulating leukocyte count were noted
