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However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)

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In the STZ animal model of AD, a chronic treatment with the CB 1 receptor agonist ACEA induced a reduction of nitric oxide (NO) accompanied by an improvement of the short- and long-term working memory measured by novel object recognition test (van der Stelt et al., 2006)