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All the evidence, taken together, provides a consistent and plausible mechanism for a causal relationship and is strongly supportive of trichloroethylene being a human carcinogen after long-term exposure to high doses, such as occupational exposures described in both studies conducted in Germany (Henschler et al

10.1529/biophysj.107.112565 144 WuZ.GengY.LuX.ShiY.WuG.ZhangM.et al (2019)

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Together with the chemical barrier of the mucosal layer and the cellular immune system, the epithelial cell layer performs a pivotal role as the first physical barrier against external factors and maintains a symbiotic relationship with commensal bacteria

marneffei from both ATCC200051 and ATCC18224 strains but was not inducible under H 2 O 2 exposure