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Mechanisms and treatment of organ failure in sepsis

Targeted de-repression of neuronal Nrf2 inhibits -synuclein accumulation

Importantly, the involvement of other mechanism(s) accounting for the pharmacological efficacy of DMF was based on the observation that DMF showed equal clinical benefit in acute experimental autoimmune encephalomyelitis (EAE) in both Nrf2 + / + and Nrf2 / mice [4]
Thats why some physicians start patients on one before adding the second
