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The same study found that KLF4 overexpression in human umbilical vein endothelial cells resulted in direct binding of KLF4 to the HBA proximal promoter [as detected by chromatin immunoprecipitation (ChIP)] (148)

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216 In addition, silver nanoparticles loaded with the anti-CD20 antibody rituximab can rapidly be internalized by chronic lymphocytic leukemia (CLL) cells, and significantly prolong survival in CLL xenograft models compared with unconjugated single agents